CYCP2;1 integrates genetic and nutritional information to promote meristem cell division in Arabidopsis
| Autor: | Katerina Bisova, Linda Peng, Peter L. Chang, Xuelin Wu, Anna Skylar |
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| Rok vydání: | 2014 |
| Předmět: |
0106 biological sciences
Transcriptional Activation Sucrose Cell division Meristem Arabidopsis Biology Genes Plant 01 natural sciences 03 medical and health sciences Cyclin-dependent kinase CYCP2 Gene Expression Regulation Plant Sugar signal Cyclins Mitosis Transcription factor Molecular Biology 030304 developmental biology Cell Proliferation Genetics Homeodomain Proteins 0303 health sciences Arabidopsis Proteins STIP Cell Biology Cell cycle biology.organism_classification Cyclin-Dependent Kinases Cell biology Seedlings biology.protein Signal transduction Cell Division 010606 plant biology & botany Developmental Biology |
| Zdroj: | Developmental biology. 393(1) |
| ISSN: | 1095-564X |
| Popis: | In higher plants, cell cycle activation in the meristems at germination is essential for the initiation of post-embryonic development. We previously identified the signaling pathways of homeobox transcription factor STIMPY and metabolic sugars as two interacting branches of the regulatory network that is responsible for activating meristematic tissue proliferation in Arabidopsis. In this study, we found that CYCP2;1 is both a direct target of STIMPY transcriptional activation and an early responder to sugar signals. Genetic and molecular studies show that CYCP2;1 physically interacts with three of the five mitotic CDKs in Arabidopsis, and is required for the G2 to M transition during meristem activation. Taken together, our results suggest that CYCP2;1 acts as a permissive control of cell cycle progression during seedling establishment by directly linking genetic control and nutritional cues with the activity of the core cell cycle machinery. |
| Databáze: | OpenAIRE |
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