Abstract not submitted for online publication
| Autor: | Laura Eckard, Leta K. Nutt, Si-lng Chen, Francis McCoy |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
0303 health sciences
biology business.industry Caspase 2 Cell Xenopus General Medicine Metabolism biology.organism_classification General Biochemistry Genetics and Molecular Biology 3. Good health Cell biology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Apoptosis Ca2+/calmodulin-dependent protein kinase biology.protein Phosphorylation Medicine business Reprogramming 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | BMC Proceedings. 6 |
| ISSN: | 1753-6561 |
| DOI: | 10.1186/1753-6561-6-s3-p36 |
| Popis: | Background The metabolic state of a cell is an important factor in whether or not it engages its apoptotic machinery. Furthermore, reprogramming energy metabolism is now recognized as a hallmark of cancer; so understanding how metabolism regulates apoptosis is crucial. Recently it has been demonstrated that CaMKII serves as a link between metabolic state and apoptosis [1]. Using the Xenopus laevis oocyte extract, it was shown that addition of glucose-6-phosphate (G6P) induced an inhibitory phosphorylation of caspase 2, mediated via CaMKII. However, the mechanisms of how G6P and metabolism regulate CaMKII still remain unclear. The aim of this study is to investigate the underlying mechanisms of how metabolism regulates CaMKII activity. |
| Databáze: | OpenAIRE |
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