Fibronectin and integrin alpha 5 play requisite roles in cardiac morphogenesis
| Autor: | Maria V. Pulina, Shuan-Yu Hou, Sophie Astrof, Ashok Mittal |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Integrin Morphogenesis Article Mice 03 medical and health sciences 0302 clinical medicine FGF8 Cell Movement Animals Cell Lineage Outflow tract Integrin a5 Cell adhesion Fibronectin Molecular Biology Cell Proliferation 030304 developmental biology 0303 health sciences biology Heart development Myocardium Gene Expression Regulation Developmental Heart Cell Biology Fibronectins Cell biology Mice Inbred C57BL Mutation Microscopy Electron Scanning biology.protein ISL1 Female Signal transduction Cardiac Dimerization 030217 neurology & neurosurgery Integrin alpha5beta1 Signal Transduction Developmental Biology |
| Zdroj: | Developmental Biology. 381(1):73-82 |
| ISSN: | 0012-1606 |
| DOI: | 10.1016/j.ydbio.2013.06.010 |
| Popis: | Fibronectin and its major receptor, integrin α5β1 are required for embryogenesis. These mutants have similar phenotypes, although, defects in integrin α5-deficient mice are milder. In this paper, we examined heart development in those mutants, in which the heart is formed, and discovered that both fibronectin and integrin α5 were required for cardiac morphogenesis, and in particular, for the formation of the cardiac outflow tract. We found that Isl1+ precursors are specified and migrate into the heart in fibronectin- or integrin α5-mutant embryos, however, the hearts in these mutants are of aberrant shape, and the cardiac outflow tracts are short and malformed. We show that these defects are likely due to the requirement for cell adhesion to fibronectin for proliferation of myocardial progenitors and for Fgf8 signaling in the pharyngeal region. |
| Databáze: | OpenAIRE |
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