Rare germline variants in ATM are associated with chronic lymphocytic leukemia

Autor:	Stacey M. Fernandes, Adam Kiezun, Catherine J. Wu, Samira Bahl, Eric S. Lander, Sandra Robrecht, Atanas Kamburov, Eugen Tausch, Esther Rheinbay, Haesook T. Kim, Dan-Avi Landau, Siddha Kasar, Ma. Reina Improgo, Grace Tiao, Jennifer R. Brown, Weijie Poh, Gad Getz, Kevin Hoang, Jasmin Bahlo, Amaro Taylor-Weiner, Stephan Stilgenbauer, Carrie Cibulskis, Kirsten Fischer, Stacey Gabriel, Michael Hallek
Rok vydání:	2017
Předmět:	0301 basic medicine Adult Male Cancer Research Chronic lymphocytic leukemia Ataxia Telangiectasia Mutated Proteins Biology Germline Article 03 medical and health sciences 0302 clinical medicine Gene Frequency immune system diseases hemic and lymphatic diseases medicine Missense mutation Humans Genetic Predisposition to Disease neoplasms Gene Germ-Line Mutation Genetic association Aged Aged 80 and over Case-control study Cancer Hematology Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell 3. Good health Leukemia 030104 developmental biology Oncology 030220 oncology & carcinogenesis Case-Control Studies Immunology Female
Zdroj:	Leukemia
ISSN:	1476-5551
Popis:	Chronic lymphocytic leukemia (CLL) is a highly heritable cancer, with a 7.5-fold increased risk in first-degree relatives.1 However, inherited predisposition to CLL remains largely unexplained by traditional linkage or genome-wide association studies. Here, we hypothesized that CLL heritability might arise from rare coding variants not analyzed in previous studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e858bee9c00e9a55005b21604da437 https://pubmed.ncbi.nlm.nih.gov/28652578 Zobrazit plný text záznamu Full text from SpringerLink