Enriching activities during childhood are associated with variations in functional connectivity patterns later in life
| Autor: | Arthur F. Kramer, Edward McAuley, Tim P. Morris, Sheeba Arnold Anteraper, Charles H. Hillman, Meishan Ai, Alfonso Nieto Castanon, Susan Whitfield-Gabrieli, Laura Chaddock-Heyman |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Aging Hippocampus Prefrontal Cortex Somatosensory system Amygdala Article Life Change Events 03 medical and health sciences Executive Function 0302 clinical medicine Cognitive Reserve medicine Humans Insular Cortex Association (psychology) Cognitive reserve Aged General Neuroscience Functional connectivity Age Factors Brain Middle Aged 030104 developmental biology medicine.anatomical_structure Orbitofrontal cortex Female Neurology (clinical) Geriatrics and Gerontology Psychology Neuroscience Insula 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Neurobiol Aging |
| ISSN: | 1558-1497 |
| Popis: | Enriching early life experiences (e.g., sport, art, music, volunteering, language learning) during a critical period of brain development may promote structural and functional brain changes that are still present decades later (>60 years). We assessed whether a greater variety of enriching early life activities (EELA) before age 13 years were associated with individual differences in cortical and subcortical (hippocampus and amygdala) structure and function later in life (older adults aged 60–80 years). Results indicated no association between EELA and amygdala and hippocampus volumes, but higher functional connectivity between the amygdala and the insula was associated with more variety of EELA. EELA was not associated with cortical thickness controlling for sex, but sex-specific associations with the right pars opercularis were found. EELA was further associated with variations in functional connectivity patterns of the orbitofrontal cortex, driven by connecitivty to regions within the visual, somatosensory and limbic networks. Early life enriching activities appear to contribute to potential mechanisms of cognitive reserve (functional processes) more so than brain reserve (structure) later in life. |
| Databáze: | OpenAIRE |
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