Optimization of the Natural Product Calothrixin A to Discover Novel Dual Topoisomerase I and II Inhibitors with Improved Anticancer Activity
| Autor: | Xiaohong Yang, Zhi-Peng Wang, Sichuan Xiang, Daoqiang Wang, Yi Zhao, Dong Luo, Yanfei Qiu, Chao Huang, Jian Guo, Yuanwei Dai, Shao-Lin Zhang, Yun He |
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| Rok vydání: | 2022 |
| Předmět: |
Biological Products
Water Antineoplastic Agents Indole Alkaloids Mice Structure-Activity Relationship DNA Topoisomerases Type II DNA Topoisomerases Type I Cell Line Tumor Drug Discovery Animals Humans Topoisomerase II Inhibitors Molecular Medicine Drug Screening Assays Antitumor Topoisomerase I Inhibitors Cell Proliferation |
| Zdroj: | Journal of Medicinal Chemistry. 65:8040-8061 |
| ISSN: | 1520-4804 0022-2623 |
| Popis: | Calothrixin A ( |
| Databáze: | OpenAIRE |
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