Analysis of acute vascular damage after photodynamic therapy using benzoporphyrin derivative (BPD)
| Autor: | E Abang, Peter K. Kik, T. J. Wieman, Michael T. Tseng, P S Haydon, Victor H. Fingar, Patricia B. Cerrito |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Porphyrins medicine.medical_treatment Chondrosarcoma Bone Neoplasms Photodynamic therapy Microcirculation Rats Sprague-Dawley chemistry.chemical_compound vascular effects chondrosarcoma Pharmacokinetics mental disorders medicine Animals Photosensitizer Vascular Diseases Fluorescein Fluorescent Dyes Photosensitizing Agents business.industry Regular Article BPD Blood flow Verteporfin Rats Treatment Outcome Photochemotherapy photodynamic therapy Oncology chemistry business Intravital microscopy medicine.drug |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6690271 |
| Popis: | Benzoporphyrin derivative monoacid ring A (BPD-MA, verteporfin) is currently under investigation as a photosensitizer for photodynamic therapy (PDT). Since BPD exhibits rapid pharmacokinetics in plasma and tissues, we assessed damage to tumour and muscle microvasculature when light treatment for PDT was given at short times after injection of photosensitizer. Groups of rats with chondrosarcoma were given 2 mg kg−1 of BPD intravenously 5 min to 180 min before light treatment of 150 J cm−2 690 nm. Vascular response was monitored using intravital microscopy and tumour cure was monitored by following regrowth over 42 days. For treatment at 5 or 30 min after BPD injection, blood flow stasis was limited to tumour microvasculature with lesser response in the surrounding normal microvasculature, indicating selective targeting for damage. No acute changes were observed in vessels when light was given 180 min after BPD injection. Tumour regression after light treatment occurred in all animals given PDT with BPD. Long-term tumour regression was greater in animals treated 5 min after BPD injection and least in animals given treatment 180 min after drug injection. The correlation between the timing for vascular damage and cure implies that blood flow stasis plays a significant role in PDT-induced tumour destruction. © 1999 Cancer Research Campaign |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|