Accelerated growth in short children with chronic renal failure treated with both strict dietary therapy and recombinant growth hormone
| Autor: | A. L. Sweeney, K. F. Jureidini, Paul Henning, R J Hogg, J. L. Penfold, M. J. Van Renen |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Nephrology
Male medicine.medical_specialty Adolescent Statistics as Topic Renal function Blood Sedimentation Growth Kidney Short stature Bone and Bones Internal medicine medicine Humans Urea Histidine Testosterone Amino Acids Child Growth Disorders business.industry Dietary management Bone age Combined Modality Therapy Recombinant Proteins Accelerated Growth Radiography Endocrinology El Niño Child Preschool Creatinine Growth Hormone Pediatrics Perinatology and Child Health Food Fortified Chronic renal failure Kidney Failure Chronic Phosphorus Dietary Calcium Dietary Proteins medicine.symptom business |
| Zdroj: | Pediatric nephrology (Berlin, Germany). 6(5) |
| ISSN: | 0931-041X |
| Popis: | In a 12-month study, nine boys, aged 4.8-15.6 years, with bone ages 4.6-13 years, with moderate to severe chronic renal failure and resultant growth failure were treated with daily recombinant human growth hormone (rhGH), in conjunction with a strict low-protein/low-phosphate diet supplemented with keto and amino forms of the essential amino acids, histidine and additional energy. Improved growth had previously been observed with this dietary management over that obtained with conventional treatment for chronic renal failure. Each child had been on this diet for at least 2 years before rhGH was commenced. Mean height velocity increased from 4.6 +/- 1.3 to 9.0 +/- 1.3 cm/year (P0.001) in the pre-pubertal group, and in the pubertal group from 5.4 +/- 1.4 to 10.4 +/- 1.8 cm/year (P0.01). The mean height velocity standard deviation scores (SDSs) increased from -1.2 +/- 0.6 to +2.3 +/- 0.9 (P0.001) in the pre-pubertal group and from -0.4 +/- 0.6 to +1.9 +/- 1.1 (P0.01) in the pubertal group. Mean height SDS for chronological age increased from -2.2 +/- 0.7 to -1.5 +/- 0.5 (P0.01) in the pre-pubertal group and from -1.9 +/- 0.7 to -1.3 +/- 0.9 in the pubertal group (P0.02). There was no significant deterioration in renal function or renal bone disease, and bone age did not advance more than chronological age over the 12-month period. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink