Fortified Antibiotic Ointment in Bacterial Keratitis
| Autor: | Larrie D. Sarff, Kathy S. Divine, Eileen M. Burd, Daniel N. Skorich, Robert A. Hyndiuk, Starkey D. Davis |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Keratitis
medicine.medical_specialty Traditional medicine medicine.drug_class business.industry Antibiotics Bacterial keratitis medicine.disease Placebo eye diseases Surgery Ointments Solutions Ophthalmology Pseudomonas aeruginosa medicine Animals Pseudomonas Infections Gentamicin Rabbits Gentamicins business medicine.drug |
| Zdroj: | American Journal of Ophthalmology. 105:239-243 |
| ISSN: | 0002-9394 |
| Popis: | We conducted experiments to determine the effectiveness of fortified antibiotic ointment in the treatment of Pseudomonas keratitis in rabbits. We evaluated gentamicin ointment (3, 10, 20, and 40 mg/g), gentamicin solution (3 and 10 mg/ml), and placebo, each given every 30 minutes. We also examined the effectiveness of fortified ointment given in extended treatment intervals. In short-term trials, commercial-strength gentamicin solution (3 mg/ml) was therapeutically superior (P less than .001) to commercial-strength gentamicin ointment (3 mg/g) in reducing corneal bacterial colony counts. No significant difference in antimicrobial effect was noted between fortified gentamicin ointment and fortified gentamicin solution at 30-minute treatment intervals. Fortified gentamicin ointment reduced colony counts even at extended treatment intervals of up to four hours in a severe keratitis model. |
| Databáze: | OpenAIRE |
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