Manganese-Catalyzed Electrochemical Deconstructive Chlorination of Cycloalkanols via Alkoxy Radicals
| Autor: | Benjamin D. W. Allen, Alex C. Seastram, Tom McBride, Louis C. Morrill, Duncan L. Browne, Thomas Wirth, Mishra Deepak Hareram |
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| Rok vydání: | 2019 |
| Předmět: |
Letter
Recirculating flow 010405 organic chemistry Chemistry Radical Organic Chemistry Halogenation Substrate (chemistry) chemistry.chemical_element Manganese 010402 general chemistry Electrochemistry Biochemistry 01 natural sciences Combinatorial chemistry Addition/Correction 0104 chemical sciences Catalysis polycyclic compounds Alkoxy group Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters |
| ISSN: | 1523-7060 |
| DOI: | 10.26434/chemrxiv.9275441.v1 |
| Popis: | A manganese-catalyzed electrochemical deconstructive chlorination of cycloalkanols has been developed. This electrochemical method provides access to alkoxy radicals from alcohols and exhibits a broad substrate scope, with various cyclopropanols and cyclobutanols converted into synthetically useful β- and γ-chlorinated ketones (40 examples). Furthermore, the combination of recirculating flow electrochemistry and continuous inline purification was employed to access products on gram scale. |
| Databáze: | OpenAIRE |
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