Broad and Efficient Control of Klebsiella Pathogens by Peptidoglycan-Degrading and Pore-Forming Bacteriocins Klebicins
| Autor: | Erna Denkovskienė, Astra Vitkauskienė, Benita Stočkūnaitė, Steve Schulz, Aušra Ražanskienė, Urtė Starkevič, Audrius Misiūnas, Anatoli Giritch, Yuri Gleba, Šarūnas Paškevičius, Simone Hahn-Löbmann |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Klebsiella Salmonella Gram-negative bacteria Bacterial toxins 030106 microbiology lcsh:Medicine medicine.disease_cause Article Microbiology Recombinant protein therapy 03 medical and health sciences Bacteriocins Bacteriocin Pseudomonas Escherichia Escherichia coli medicine Humans Clinical microbiology lcsh:Science Multidisciplinary biology lcsh:R food and beverages biology.organism_classification Multiple drug resistance 030104 developmental biology Plant biotechnology lcsh:Q Bacteria |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019) Scientific reports, London : Nature Publishing Group, 2019, vol. 9, no. 1, 15422, p. 1-11 Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-51969-1 |
| Popis: | Gram-negative bacteria belonging to the genus Klebsiella are important nosocomial pathogens, readily acquiring resistance to all known antibiotics. Bacteriocins, non-antibiotic antibacterial proteins, have been earlier proposed as potential therapeutic agents for control of other Gram-negative species such as Escherichia, Pseudomonas and Salmonella. This study is the first report describing pore-forming and peptidoglycan-degrading bacteriocins klebicins from Klebsiella. We have identified, cloned, expressed in plants and characterized nine pore-forming and peptidoglycan-degrading bacteriocins from different Klebsiella species. We demonstrate that klebicins can be used for broad and efficient control of 101 of the 107 clinical isolates representing five Klebsiella species, including multi-drug resistant pathovars and pathovars resistant to carbapenem antibiotics. |
| Databáze: | OpenAIRE |
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