Ceramide expression in relation to breast cancer molecular subtypes in Saudi women
| Autor: | Danah Alrabeeah, Monira Alwhaibi, Maria Arafah, Nasser B. Alsaleh, Khalid Al Saleh, Musaed Alkholief, Aws Alshamsan, Aliyah Almomen, Norah A Alsaigh, Abdullah Alshememry |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology Ceramide medicine.medical_specialty medicine.drug_class Molecular subtypes Saudi Arabia Pharmaceutical Science RM1-950 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer Internal medicine medicine Receptor Pathological Pharmacology biology business.industry Ceramide expression medicine.disease Sphingolipid 030104 developmental biology chemistry Estrogen 030220 oncology & carcinogenesis Monoclonal biology.protein lipids (amino acids peptides and proteins) Original Article Therapeutics. Pharmacology Antibody business Biomarkers |
| Zdroj: | Saudi Pharmaceutical Journal : SPJ Saudi Pharmaceutical Journal, Vol 29, Iss 6, Pp 609-615 (2021) |
| ISSN: | 2213-7475 1319-0164 |
| Popis: | Background/Introduction Despite advances in the diagnosis and management of breast cancer (BC), it is still associated with high mortality rates. New biomarkers are being developed for the diagnosis, treatment, and prediction of responses of BC. Ceramide (CER), a bioactive sphingolipid, has emerged recently as a useful diagnostic tool in several types of tumors. In this study, we evaluated CER expression in invasive BC and assessed its relation to the molecular subtypes of BC. Materials and methods The clinical data and histopathological slides of 50 patients with invasive ductal carcinoma were retrieved and reviewed. The cases were then stained with a mouse monoclonal anti-ceramide antibody. Pearson correlation was used to assess the correlation between CER percentage and intensity and other clinical and pathological variables. Results CER expression showed a direct relationship with estrogen and progesterone receptors Allred scores. However, it showed an inverse relation with tumor grade, HER2/neu status and Ki-67 index. Conclusions CER expression is likely to be associated with luminal BC molecular subtypes. However, more research is needed to confirm these results and to explore its relation to the different clinical outcomes, including response to treatment and prognosis. |
| Databáze: | OpenAIRE |
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