An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction
Autor: | Ying Yu, Yimei Wu, Gu-Feng Xu, Meng-Xi Guo, Kamran Ullah, Ye Chun Ruan, Lu-Yang Jin, He-Feng Huang, Chengliang Zhou, Jian-Zhong Sheng, Xian-Hua Lin, Yinyu Wang, Hsiao Chang Chan, Priscilla Yu, Xin-Mei Liu, Lin Tang, Hao Chen, Tanzil Ur Rahman, Dan-Dan Wu |
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Rok vydání: | 2019 |
Předmět: |
Adult
0301 basic medicine Spiral artery medicine.medical_specialty DNA Complementary animal structures Placenta Blood Pressure Pregnancy Proteins General Biochemistry Genetics and Molecular Biology Preeclampsia 03 medical and health sciences 0302 clinical medicine Mineralocorticoid receptor Pre-Eclampsia Pregnancy Risk Factors medicine.artery Internal medicine Human Umbilical Vein Endothelial Cells medicine Humans Vascular Diseases Endothelial dysfunction Aldosterone Placenta Growth Factor General Environmental Science Tube formation business.industry Endothelial Cells Umbilical artery medicine.disease Pathophysiology Alternative Splicing Receptors Mineralocorticoid 030104 developmental biology Endocrinology medicine.anatomical_structure 030220 oncology & carcinogenesis embryonic structures RNA Female General Agricultural and Biological Sciences business |
Zdroj: | Science China Life Sciences. 63:388-400 |
ISSN: | 1869-1889 1674-7305 |
Popis: | The pathophysiology of preeclampsia (PE) remains unclear. PE spiral artery remodeling dysfunction and PE offspring cardiovascular future development has been a worldwide concern. We collected placental and umbilical artery samples from nor-motensive and PE pregnancies. Mineralocorticoid receptor (MR) and its alternative splicing variant (ASV) expression and their biological effects on PE were examined. An MR ASV was found to be highly expressed in all PE samples and slightly expressed in about half of the normotensive samples (umbilical artery, ~57.58%; placenta, ~36.84%). The MR ASV expression was positively associated with blood pressure in both groups. The MR ASV protein changed the aldosterone-induced expression pattern of MR target genes related to ion exchanges and cell signaling pathways. The MR ASV can also impair the proliferation, migration, and tube formation ability of endothelial cells. These findings indicate that MR ASV in PE placenta plays a pathogenic role in PE pathophysiology, especially in endothelial dysfunction, and the existence of the MR ASV in PE umbilical artery provides a new direction in the study of PE offspring with increased risk of cardiovascular diseases. |
Databáze: | OpenAIRE |
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