Erythrophagocytic tumour cells in melanoma and squamous cell carcinoma of the skin
| Autor: | A. Peydró, Antonio Llombart-Bosch, Carlos Monteagudo, C. Illueca, Carmen Carda, Esperanza Jordá |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Pathology medicine.medical_specialty Erythrocytes Skin Neoplasms Histology Malignant histiocytosis Biology Pathology and Forensic Medicine Cytokeratin Phagocytosis Antigens Neoplasm Biomarkers Tumor medicine Humans Melanoma Histiocyte Aged Aged 80 and over Mucin-1 General Medicine medicine.disease Immunohistochemistry Erythrophagocytosis Neoplasm Proteins Microscopy Electron Haematopoiesis medicine.anatomical_structure Epidermoid carcinoma Carcinoma Squamous Cell Bone marrow Melanoma-Specific Antigens |
| Zdroj: | Histopathology. 31:367-373 |
| ISSN: | 1365-2559 0309-0167 |
| DOI: | 10.1046/j.1365-2559.1997.2670867.x |
| Popis: | Aims: Erythrophagocytosis is a characteristic feature of tumour cells in malignant histiocytosis, some leukaemias, lymphomas, and also reactive histiocytes in the haemophagocytic syndrome associated with a variety of infections and neoplasms. It has also been found exceptionally in metastatic malignant epithelial cells in bone marrow and lymph nodes. We present two cases, a cutaneous malignant melanoma and an acantholytic squamous cell carcinoma, in which erythrophagocytosis by tumour cells was demonstrable by both light and electron microscopy. Methods and results: The melanocytic and squamous nature of these cells was supported by the immunohistochemical detection of HMB45, S100, and NKI-C3 in the former, and cytokeratin and EMA in the latter, and at ultrastructural level by the presence of melanosomes and tonofilaments, respectively. Conclusions: This is, to our knowledge, the first documented report of erythrophagocytic tumour cells in human melanomas and primary carcinomas. Biological considerations apart, this unusual feature can prove to be of value to avoid a misdiagnosis of a variety of haematopoietic malignancies. |
| Databáze: | OpenAIRE |
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