Use of Functional Magnetic Resonance Imaging to Assess How Motor Phenotypes of Parkinson's Disease Respond to Deep Brain Stimulation
| Autor: | Ilknur Telkes, Roy Hwang, Marisa DiMarzio, Michael D. Staudt, Jennifer Durphy, Damian S. Shin, Radhika Madhavan, Tanweer Rashid, Julia Prusik, Era Hanspal, Julie G. Pilitsis, Michael Gillogly, Jacquelyn MacDonell, Paul J. Feustel, Jeffrey Michael Ashe, Eric Fiveland, Suresh Joel, Ileana Hancu |
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| Rok vydání: | 2019 |
| Předmět: |
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medicine.medical_specialty Parkinson's disease Deep brain stimulation medicine.medical_treatment Deep Brain Stimulation 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Aged Brain Mapping medicine.diagnostic_test Supplementary motor area business.industry Brain Parkinson Disease General Medicine Middle Aged medicine.disease SMA Magnetic Resonance Imaging Subthalamic nucleus Anesthesiology and Pain Medicine medicine.anatomical_structure Globus pallidus Phenotype nervous system Neurology Cardiology Female Neurology (clinical) Primary motor cortex business Functional magnetic resonance imaging 030217 neurology & neurosurgery |
| Zdroj: | Neuromodulation : journal of the International Neuromodulation SocietyREFERENCES. 23(4) |
| ISSN: | 1525-1403 |
| Popis: | BACKGROUND Deep brain stimulation (DBS) is a well-accepted treatment of Parkinson's disease (PD). Motor phenotypes include tremor-dominant (TD), akinesia-rigidity (AR), and postural instability gait disorder (PIGD). The mechanism of action in how DBS modulates motor symptom relief remains unknown. OBJECTIVE Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) was used to determine whether the functional activity varies in response to DBS depending on PD phenotypes. MATERIALS AND METHODS Subjects underwent an fMRI scan with DBS cycling ON and OFF. The effects of DBS cycling on BOLD activation in each phenotype were documented through voxel-wise analysis. For each region of interest, ANOVAs were performed using T-values and covariate analyses were conducted. Further, a correlation analysis was performed comparing stimulation settings to T-values. Lastly, T-values of subjects with motor improvement were compared to those who worsened. RESULTS As a group, BOLD activation with DBS-ON resulted in activation in the motor thalamus (p |
| Databáze: | OpenAIRE |
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