Genome-wide association studies reveal additional related loci for fatty acid composition in a Duroc pig multigenerational population

Autor:	Shinji Arata, Keiichi Suzuki, Hironori Sakuma, Sachiko Egawa, Tomomi Saito, Satoshi Miyashita, Kimiko Kohira, Shuji Sato, Takashi Kikuchi, Yoshinobu Uemoto
Rok vydání:	2017
Předmět:	0301 basic medicine Candidate gene Genotype Genotyping Techniques Quantitative Trait Loci Sus scrofa Population Single-nucleotide polymorphism Genome-wide association study Quantitative trait locus Polymorphism Single Nucleotide Chromosomes 03 medical and health sciences chemistry.chemical_compound Animals Humans education Genetic Association Studies Fatty acid synthesis Genetics education.field_of_study biology Muscles Fatty Acids General Medicine Pedigree Fatty acid synthase Phenotype 030104 developmental biology chemistry Body Composition biology.protein Intramuscular fat Fatty Acid Synthases General Agricultural and Biological Sciences Stearoyl-CoA Desaturase Genome-Wide Association Study
Zdroj:	Animal Science Journal. 88:1482-1490
ISSN:	1344-3941
DOI:	10.1111/asj.12793
Popis:	The aim of the present study was to detect quantitative trait loci affecting fatty acid composition in back fat and intramuscular fat in a Duroc pig population comprising seventh-generation pedigrees using genome-wide association studies (GWAS). In total, 305 animals were genotyped using single nucleotide polymorphisms (SNPs) array and five selected SNPs from regions containing known candidate genes related to fatty acid synthesis or metabolism. In total, 24 genome-wide significant SNP regions were detected in 12 traits, and 76 genome-wide suggestive SNP regions were detected in 33 traits. The Sus scrofa chromosome (SSC) 7 at 10.3 Mb was significantly associated with C17:0 in intramuscular fat, while the SSC9 at 13.6 Mb was significantly associated with C14:0 in intramuscular fat. The SSC12 at 1.0 Mb was significantly associated with C14:0 in back fat and the SSC14 at 121.0 Mb was significantly associated with C18:0 in intramuscular fat. These regions not only replicated previously reported loci containing some candidate genes involved in fatty acid composition (fatty acid synthase and stearoyl-CoA desaturase) but also included several additional related loci.
Databáze:	OpenAIRE
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