Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck

Autor: Yu Lei, Ariane Nguyen, Neck Spore Program, Jonathan B. McHugh, Dafydd G. Thomas, Laura S. Rozek, Gregory T. Wolf, William P. Winter, Emily Bellile, Christopher R. Donnelly, Lahin Amlani
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Cancer Research
Epithelial-Mesenchymal Transition
Biopsy
Vimentin
Kaplan-Meier Estimate
Disease-Free Survival
Article
03 medical and health sciences
0302 clinical medicine
Lymphocytes
Tumor-Infiltrating
Antigens
CD
Biomarkers
Tumor
Medicine
Humans
Neoplasm Invasiveness
Epithelial–mesenchymal transition
Tissue microarray
biology
Oncogene
medicine.diagnostic_test
Tumor-infiltrating lymphocytes
business.industry
Proportional hazards model
Squamous Cell Carcinoma of Head and Neck
SOXB1 Transcription Factors
Middle Aged
Cadherins
Prognosis
Squamous carcinoma
030104 developmental biology
Oncology
Head and Neck Neoplasms
Tissue Array Analysis
030220 oncology & carcinogenesis
biology.protein
Cancer research
Female
Oral Surgery
Neoplasm Recurrence
Local
business
Follow-Up Studies
Zdroj: Oral oncology. 87
ISSN: 1879-0593
Popis: INTRODUCTION: Disruption of E-cadherin function and increased expression of vimentin and the transcriptional oncogene, SOX2, are thought to characterize epithelial to mesenchymal transition (EMT) in HNSCC that contributes to invasive and metastatic behavior. To determine if such changes relate to prognosis or host immune response, expression of these markers and correlations with clinical characteristics, histologic worst pattern of invasion (WPOI) and tumor infiltrating lymphocytes (TIL) and survival were assessed. METHODS: Immunohistologic expression of markers was determined in tissue microarrays from 274 previously untreated HNSCC patients. Expression was correlated with levels of TILs in microcores and WPOI in biopsy specimens. Correlations were assessed by Kruskal-Wallis testing and Spearman correlation coefficients where appropriate. Overall and relapse-free survival were analyzed with Cox proportional hazards models. Median follow up was 60.0 months. RESULTS: Loss of E-cadherin expression was significantly associated with low or absent SOX2 expression (R=0.433, p
Databáze: OpenAIRE
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