Repeated evolution of an acetate-crossfeeding polymorphism in long-term populations of Escherichia coli
| ISSN: | 1537-1719 0737-4038 |
|---|---|
| DOI: | 10.1093/oxfordjournals.molbev.a025984 |
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d471ecf7a934a04345b6dd5c23f20b https://doi.org/10.1093/oxfordjournals.molbev.a025984 |
| Rights: | OPEN |
| Přírůstkové číslo: | edsair.doi.dedup.....27d471ecf7a934a04345b6dd5c23f20b |
| Autor: | David S. Treves, Julian Adams, Shannon D. Manning |
| Rok vydání: | 1998 |
| Předmět: |
DNA Mutational Analysis
Acetate-CoA Ligase Gene Expression Locus (genetics) Acetates Biology medicine.disease_cause Evolution Molecular Gene expression Escherichia coli Genetics medicine Insertion sequence Molecular Biology Gene Ecology Evolution Behavior and Systematics Polymorphism Genetic Acetyl—CoA synthetase Phenotype Molecular biology Mutagenesis Insertional Glucose Genes Bacterial |
| Zdroj: | Molecular Biology and Evolution. 15:789-797 |
| ISSN: | 1537-1719 0737-4038 |
| DOI: | 10.1093/oxfordjournals.molbev.a025984 |
| Popis: | Six out of 12 independent replicate populations of Escherichia coli maintained in long-term glucose-limited continuous culture for up to approximately 1,750 generations evolve polymorphisms maintained by acetate crossfeeding. In all cases, the acetate-crossfeeding phenotype is associated with semiconstitutive overexpression of acetyl CoA synthetase, which allows for the enhanced uptake of low levels of exogenous acetate. Mutations in the 5' regulatory region of the acetyl CoA synthetase locus are responsible for all the acetate crossfeeding phenotypes found. These changes were either transposable-element insertions or a single T-->A nucleotide substitution at position -93 relative to the acs gene translation start site. |
| Databáze: | OpenAIRE |
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