PET imaging biomarkers in head and neck cancer
| Autor: | Hildebrandt, Malene, Gerke, Oke, Baun, Christina, Falch Braas, Kirsten, Ansholm, J, Farahani, Ziba, Larsen, L, Duvnjak, Sandra, S, Kent, Bak Jylling, Anne Marie, Ewertz, Marianne, Alavi, Abass, Høilund-Carlsen, Poul Flemming |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
medicine.medical_specialty Imaging biomarker PET/CT medicine.medical_treatment Internal medicine medicine Carcinoma Biomarkers Tumor Humans Radiology Nuclear Medicine and imaging Head and neck cancer PET-CT medicine.diagnostic_test business.industry General Medicine medicine.disease Head and neck squamous-cell carcinoma Radiation therapy Positron emission tomography Head and Neck Neoplasms Positron-Emission Tomography Carcinoma Squamous Cell Molecular imaging Radiopharmaceuticals Nuclear medicine business |
| Zdroj: | Hildebrandt, M, Gerke, O, Baun, C, Falch Braas, K, Ansholm, J, Farahani, Z, Larsen, L, Duvnjak, S, S, K, Bak Jylling, A M, Ewertz, M, Alavi, A & Høilund-Carlsen, P F 2015, ' PET imaging biomarkers in head and neck cancer ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 42, P573, pp. 613-622 . https://doi.org/10.1007/s00259-014-2972-7 |
| ISSN: | 1619-7089 |
| Popis: | In locally advanced head and neck squamous cell carcinoma (HNSCC), the role of imaging becomes more and more critical in the management process. In this framework, molecular imaging techniques such as PET allow noninvasive assessment of a range of tumour biomarkers such as metabolism, hypoxia and proliferation, which can serve different purposes. First, in a pretreatment setting they can influence therapy selection strategies and target delineation for radiation therapy. Second, their predictive and/or prognostic value could help enhance the therapeutic ratio in the management of HNSCC. Third, treatment modification can be performed through the generation of a molecular-based heterogeneous dose distribution with dose escalation to the most resistant parts of the tumour, a concept known as dose painting. Fourth, they are increasingly becoming a tool for monitoring response to therapy. In this review, PET imaging biomarkers used in the routine management of HNSCC or under investigation are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink