Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy

Autor: Belen Reig-Vano, Agnieszka Mocek-Płóciniak, Marta Giamberini, Bartosz Tylkowski, Krzysztof Roszkowski, Anna Bajek, Oliwia Kowalczyk, Remigiusz Tomczyk, Xavier Montané, Wojciech Pawliszak
Rok vydání: 2020
Předmět:
2019-20 coronavirus outbreak
Antioxidant
medicine.medical_treatment
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Cancer therapy
Pharmaceutical Science
Antineoplastic Agents
Review
Bioinformatics
Analytical Chemistry
dietary supplements
lcsh:QD241-441
03 medical and health sciences
Human health
0302 clinical medicine
Drug Therapy
lcsh:Organic chemistry
Neoplasms
natural health products
Drug Discovery
Humans
cancer
Medicine
anticancer therapy
Physical and Theoretical Chemistry
Beneficial effects
polyphenols
030304 developmental biology
Flavonoids
0303 health sciences
business.industry
Organic Chemistry
food and beverages
Cancer
Drug Synergism
phytochemicals
medicine.disease
antioxidants
Chemistry (miscellaneous)
Polyphenol
030220 oncology & carcinogenesis
Molecular Medicine
business
Zdroj: Molecules, Vol 25, Iss 3342, p 3342 (2020)
Molecules
ISSN: 1420-3049
Popis: The development of anticancer therapies that involve natural drugs has undergone exponential growth in recent years. Among the natural compounds that produce beneficial effects on human health, polyphenols have shown potential therapeutic applications in cancer due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties. The possibility of combining conventional drugs—which are usually more aggressive than natural compounds—with polyphenols offers very valuable advantages such as the building of more efficient anticancer therapies with less side effects on human health. This review shows a wide range of trials in which polyphenolic compounds play a crucial role as anticancer medicines alone or in combination with other drugs at different stages of cancer: cancer initiation, promotion, and growth or progression. Moreover, the future directions in applications of various polyphenols in cancer therapy are emphasized.
Databáze: OpenAIRE
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