Independent external validation using the EORTC HNCG-ROG 1219 DAHANCA trial data of NTCP models for acute oral mucositis
| Autor: | J. Willmann, Laurence Collette, M. Sharabiani, V. Gregoire, Catherine Fortpied, Jens Overgaard, Enrico Clementel, Coen W. Hurkmans, N. Andratschke |
|---|---|
| Přispěvatelé: | University of Zurich, Sharabiani, Marjan |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty 2720 Hematology 610 Medicine & health NTCP Logistic regression 030218 nuclear medicine & medical imaging Oral mucositis External validity Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Mucositis 2741 Radiology Nuclear Medicine and Imaging Humans Radiology Nuclear Medicine and imaging Probability Stomatitis Nimorazole Receiver operating characteristic business.industry Squamous Cell Carcinoma of Head and Neck Hematology medicine.disease 10044 Clinic for Radiation Oncology Head and neck squamous-cell carcinoma External validation Logistic models DAHANCA Brier score Head and Neck Neoplasms 030220 oncology & carcinogenesis 2730 Oncology business medicine.drug |
| Zdroj: | Sharabiani, M, Clementel, E, Andratschke, N, Collette, L, Fortpied, C, Grégoire, V, Overgaard, J, Willmann, J & Hurkmans, C 2021, ' Independent external validation using the EORTC HNCG-ROG 1219 DAHANCA trial data of NTCP models for acute oral mucositis ', Radiotherapy and Oncology, vol. 161, pp. 35-39 . https://doi.org/10.1016/j.radonc.2021.04.006 |
| ISSN: | 1879-0887 |
| Popis: | Purpose To externally validate previously published Normal Tissue Complication Probability (NTCP) models developed by separate teams for grade 3 oral mucositis (g3OM). Materials and methods Two models were validated: a logistic model, based on 144 head and neck cancer (HNC) patients receiving induction chemotherapy followed by chemo-IMRT; a multivariable logistic model for prediction of g3OM for 253 patients receiving radical treatment for the head and neck squamous cell carcinoma (HNSCC). The EORTC HNCG-ROG 1219 DAHANCA trial dataset, consisting of 169 patients was used as the validation cohort. This cohort was treated with accelerated fractionated chemo-IMRT, with/without the hypoxic radiosensitizer Nimorazole for HNSCC. External validity was assessed using the scaled Brier score. Calibration was assessed in terms of calibration curves as well as measures of mean and weak calibration. Hosmer-Lemeshow was used for goodness-of-fit test. Discrimination was calculated using the area under the receiver operating curve (AUC-ROC). Results The prevalence of g3OM in the validation cohort (35.5%) was similar to that of two development cohorts, i.e. 38.7% and 31.9% for Bhide logistic and Otter multivariable logistic models respectively. The scaled Brier scores showed good overall model performance. Perfect calibration was observed in the prevalence range of 20% to 40%. AUC-ROC was acceptable in external validation (0.67). The Hosmer-Lemeshow test showed good agreement between predicted and observed outcomes for two models. Conclusion The NTCP models were validated and lead to valid predictions in a wide range of diverse treatment techniques and patient characteristics, also when Nimorazole is added as hypoxic radiosensitizer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect