Surgical Management of Primary Hyperparathyroidism—Clinicopathologic Study of 1019 Cases from a Single Institution
| Autor: | Zbigniew Niedzielski, Agata Gawrychowska, Adam Bednarczyk, Jacek Gawrychowski, Grzegorz Kowalski, Dominika Żądło, Henryk Koziołek, Grzegorz Buła |
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| Rok vydání: | 2020 |
| Předmět: |
Parathyroidectomy
medicine.medical_specialty endocrine system diseases medicine.medical_treatment lcsh:Medicine remedial surgery 030209 endocrinology & metabolism parathyroidectomy Article Surgical failure 03 medical and health sciences 0302 clinical medicine persistent hypercalcemia medicine Endocrine system primary hyperparathyroidism ectopic mediastinal localization Single institution business.industry lcsh:R Mediastinum General Medicine medicine.disease Surgery medicine.anatomical_structure Increased risk 030220 oncology & carcinogenesis Parathyroid gland business hormones hormone substitutes and hormone antagonists Primary hyperparathyroidism |
| Zdroj: | Journal of Clinical Medicine, Vol 9, Iss 3540, p 3540 (2020) Journal of Clinical Medicine Volume 9 Issue 11 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm9113540 |
| Popis: | Background: Primary hyperparathyroidism (pHPT) is an endocrine disorder characterized by hypercalcemia and caused by the presence of disordered parathyroid glands. Parathyroidectomy is the only curative therapy for pHPT, but despite its high cure rate of 95&ndash 98%, there are still cases where hypercalcemia persists after this surgical procedure. The aim of this study was to present the results of a surgical treatment of patients due to primary hyperparathyroidism and failures related to the thoracic location of the affected glands. Methods: We present a retrospective analysis of 1019 patients who underwent parathyroidectomy in our department in the period 1983&ndash 2018. Results: Among the group of 1019 operated-on patients, treatment failed in 19 cases (1.9%). In 16 (84.2%) of them, the repeated operation was successful. In total, 1016 patients returned to normocalcemia. Conclusions: Our results confirm that parathyreoidectomy is the treatment of choice for patients with primary hyperparathyroidism. The ectopic position of the parathyroid gland in the mediastinum is associated with an increased risk of surgical failure. Most parathyroid lesions in the mediastinum can be safely removed from the cervical access. |
| Databáze: | OpenAIRE |
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