In vitro glycated low-density lipoprotein interaction with human monocyte-derived macrophages
| Autor: | J.C. Siffert, A. Gugliucci Creriche, A.J.C. Stahl, S. Dumont |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Glycation End Products
Advanced Glycosylation Immunology Biological Transport Active Receptors Cell Surface In Vitro Techniques Binding Competitive Monocytes chemistry.chemical_compound Glycation medicine Humans Scavenger receptor Receptor Receptors Lipoprotein Macrophages Monocyte In vitro Lipoproteins LDL Kinetics medicine.anatomical_structure chemistry Biochemistry Low-density lipoprotein lipids (amino acids peptides and proteins) Lipoprotein |
| Zdroj: | Research in Immunology. 143:17-23 |
| ISSN: | 0923-2494 |
| DOI: | 10.1016/0923-2494(92)80075-v |
| Popis: | Human low-density lipoprotein (LDL) was glycated in vitro (5 days, glucose 50 mmol/l), labelled with 125I, and its binding and uptake by human monocyte-derived macrophages studied. Glycation produced lower binding and lower uptake. Competition experiments using unlabelled LDL (control, glycated, and acetyl-LDL) showed that most glycated LDL was taken up by the apolipoprotein-B100: E receptor pathway. Results suggest that less of the glycated LDL may enter the cells via scavenger receptors, and very minute amount via non-saturable receptor-independent pathways. |
| Databáze: | OpenAIRE |
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