Examining the common aetiology of serous ovarian cancers and basal-like breast cancers using double primaries
| Autor: | Shelley S. Tworoger, Emily C. Zabor, Megan S. Rice, Colin B. Begg |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty endocrine system diseases Ovary Breast Neoplasms Biology Neoplasms Multiple Primary 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Breast cancer breast cancer Internal medicine medicine Carcinoma Humans Cystadenocarcinoma Molecular Diagnostics Neoplasm Staging multiple primaries Ovarian Neoplasms medicine.disease Prognosis 3. Good health Cancer registry Cystadenocarcinoma Serous Serous fluid 030104 developmental biology medicine.anatomical_structure ovarian cancer Carcinoma Basal Cell 030220 oncology & carcinogenesis shared aetiology tumour subtypes Female Ovarian cancer |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 |
| Popis: | Background: The somatic molecular profiles of basal-like breast cancers and high-grade serous ovarian cancers share many similarities, leading to the hypothesis that they have similar aetiologies, in which case they should occur together in the same patient more often than expected. Methods: We identified 545 women with double independent primary cancers of the breast and ovary reported to the California Cancer Registry from 1999 to 2013 and examined the coincidence of subtype combinations. Results: For most subtype combinations the observed frequencies were similar to their expected frequencies, but in 103 observed cases vs 43.8 expected (O/E=2.35; 95% CI 1.90–2.81) a triple-negative breast tumour (typically basal-like) was matched with a serous ovarian tumour (typically high-grade). Conclusions: The results provide compelling evidence that basal-like breast cancer and high-grade serous ovarian cancer share a much more similar aetiology than breast and ovarian cancers more broadly. Further research is needed to clarify the influence of germ-line BRCA1 mutations and other risk factors on these results. |
| Databáze: | OpenAIRE |
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