Evaluation of in vitro virulence characteristics of the genus Pandoraea in lung epithelial cells
| Autor: | Jonathan Collins, Gillian Herbert, Siobhán McClean, Philip Murphy, Charles G. Gallagher, Mary Crowe, Máire Callaghan, E. Caraher |
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| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
Pandoraea apista Virulence biology interleukin MBC Betaproteobacteria Pandoraea sputorum Epithelial Cells General Medicine biology.organism_classification Microbiology Pandoraea pnomenusa Cell Line minimum bactericidal concentration Burkholderia cepacia complex CF cystic fibrosis IL Biofilms Pandoraea Medicine and Health Sciences Pandoraea norimbergensis Lung Bacteria |
| Zdroj: | Articles |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/jmm.0.47544-0 |
| Popis: | Pandoraea species are emerging opportunistic pathogens capable of causing chronic lung infections in cystic fibrosis patients. This study examined the interactions of 17 Pandoraea isolates from the five identified species (Pandoraea apista, Pandoraea norimbergensis, Pandoraea pulmonicula, Pandoraea sputorum and Pandoraea pnomenusa) plus two Pandoraea genomospecies isolates with lung epithelial cells and their ability to form biofilms in vitro. Only three isolates showed an ability to invade A549 lung epithelial cells, and only one isolate was able to form biofilms. In contrast, all isolates triggered a pronounced pro-inflammatory response, with elevation of both interleukin (IL)-6 (two- to 19-fold) and IL-8 (10- to 50-fold) above that observed for a control strain of Escherichia coli. This property is likely to be a major factor in the pathogenesis of the genus. |
| Databáze: | OpenAIRE |
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