Intestinal ischemia-reperfusion injury mediates expression of inflammatory cytokines in rats
| Autor: | Miroslava Bilecová-Rabajdová, Ján Varga, Peter Urban, Jarmila Veselá, Štefan Čikoš, Štefan Feterik, Kristína Gregová |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Physiology medicine.medical_treatment Biophysics Inflammation Systemic inflammation Polymerase Chain Reaction Proinflammatory cytokine Internal medicine medicine Animals cardiovascular diseases RNA Messenger Intestinal Mucosa Rats Wistar DNA Primers business.industry Tumor Necrosis Factor-alpha General Medicine medicine.disease Small intestine Interleukin-10 Rats Interleukin 10 Endocrinology medicine.anatomical_structure Cytokine Gene Expression Regulation Reperfusion Injury Immunology Cytokines Tumor necrosis factor alpha medicine.symptom business Reperfusion injury |
| Zdroj: | General physiology and biophysics. 34(1) |
| ISSN: | 0231-5882 |
| Popis: | The small intestine is an organ with very well developed immunological activity, responsible for synthesis of specific inflammatory mediators that participate in causing the systemic inflammation that can occur after ischemia-reperfusion injury. The aim of our work was to study mRNA expression and protein concentration of inflammatory cytokines IL-10 and TNFα in the jejunal wall after intestinal ischemia-reperfusion injury (IRI). Cytokine concentration levels confirmed the direct effect of IRI on the inflammation process. The results refer to the changes in balance between pro-inflammatory and anti-inflammatory mediators and indicate that the predominant disturbance of homeostasis after intestinal IRI is present after 1 hour of reperfusion. |
| Databáze: | OpenAIRE |
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