Conditioning adhesive contacts between the neutrophils and the endotheliocytes by Staphylococcus aureus
| Autor: | Peter Gorelkin, Svetlana N. Pleskova, Alexander Erofeev, Sergey Z. Bobyk, A V Boryakov, Ruslan N. Kriukov |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Staphylococcus aureus Neutrophils High variability Cell Communication 010402 general chemistry medicine.disease_cause 01 natural sciences Cell Line Young Adult Structural Biology medicine Cell Adhesion Adhesion force Humans Molecular Biology Microscopy Chemistry Atomic force microscopy 010401 analytical chemistry Endothelial Cells 0104 chemical sciences Membrane Biophysics Conditioning Adhesive Intracellular |
| Zdroj: | Journal of molecular recognition : JMRREFERENCES. 33(9) |
| ISSN: | 1099-1352 |
| Popis: | We have developed a model for evaluating the integral intercellular interactions in the "endotheliocyte-neutrophil" system and have shown the high variability of adhesion contacts in different donors associated with different expression profiles of neutrophils. Two methods (forсe spectroscopy-spectroscopy and scanning ion-conductance microscopy) showed a decrease in the rigidity of the membrane-cytoskeletal complex of neutrophils under the influence of Staphylococcus aureus 2879 M. Adding this strain to the "endotheliocyte-neutrophil" system caused a statistically significant decrease in the adhesion force and adhesion work, which indicates a change in the expression profile and physicochemical properties of membranes of both types of interacting cells (neutrophils and endotheliocytes). |
| Databáze: | OpenAIRE |
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