Chemotherapy regimen based on sorafenib combined with 5-FU on HIF-1α and VEGF expression and survival in advanced gastric cancer patients
| Autor: | Qingsong Xie, Hongmei Yong, Yunhong Xia, Guangyi Gao, Xueyi Zhou, Ronghui Cheng |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Sorafenib Cancer Research medicine.medical_specialty medicine.medical_treatment 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Survival rate Chemotherapy hypoxia-inducible factor-1α vascular endothelial growth factor Oncogene business.industry gastric cancer Cancer Articles medicine.disease Molecular medicine Chemotherapy regimen Vascular endothelial growth factor 030104 developmental biology chemistry 030220 oncology & carcinogenesis sorafenib business medicine.drug |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | The present study investigated the effect of combined sorafenib chemotherapy on hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression and survival time of patients with advanced gastric cancer. From January 2010 to December 2011, 92 patients diagnosed with advanced gastric cancer were selected and randomly divided into the treatment group and control group. The treatment group was treated with sorafenib chemotherapy combined with 5-fluorouracil (5-FU), and the control group received 5-FU. The treatment course was 3–4 cycles. During the same period, 46 healthy persons admitted to the Second People's Hospital of Huaian were selected as the controls. A volume of 3–4 ml peripheral blood from each patient and control was collected before and after treatment. The expression levels of HIF-1α and VEGF in peripheral blood were measured by ELISA. The survival time of patients with advanced gastric cancer was followed and analyzed. Compared with healthy controls, serum levels of HIF-1α and VEGF were significantly higher in patients with advanced gastric cancer (P |
| Databáze: | OpenAIRE |
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