Finely Tuned Temperature-Controlled Cargo Release Using Paraffin-Capped Mesoporous Silica Nanoparticles

Autor: Enrique Pérez-Payá, Laura Mondragón, Pedro Amorós, José V. Ros-Lis, Elena Aznar, Juan Soto, Ramón Martínez-Máñez, M. Dolores Marcos, Félix Sancenón
Rok vydání: 2011
Předmět:
Models
Molecular
INGENIERIA DE LA CONSTRUCCION
Guest molecules
Paraffins
Paraffin waxes
Nanoparticle
mesoporous materials
MCM-41
Phenazine derivative
Functionalized
Cell survival
QUIMICA ORGANICA
Chemical structure
X-Ray Diffraction
Safranin t
Silicon dioxide
Controlled release
Alkyl chain
Drug Carriers
Microscopy
Confocal
Molecular Structure
Octadecyltrimethoxysilane
Surface property
Temperature
Silica
General Medicine
Chemistry
Antineoplastic agent
Paraffin
HeLa cell
Porosity
Human
Materials science
Drug carrier
X ray diffraction
Surface Properties
Mesoporous silica nanoparticles
Nanotechnology
Antineoplastic Agents
Mesoporous
Catalysis
Drug interactions
Article
Microscopy
Electron
Transmission
Humans
Drug effect
Delayed release formulation
Hydrophobic layers
QUIMICA INORGANICA
General Chemistry
Mesoporous silica
Molecular gates
Mesoporous materials
Mcm 41
Confocal microscopy
Solubility
Doxorubicin
Delayed-Action Preparations
drug delivery
Drug delivery
Nanoparticles
Phenazines
nanoparticles
Mesoporous material
controlled release
molecular gates
Transmission electron microscopy
HeLa Cells
Zdroj: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
ISSN: 0044-8249
1433-7851
DOI: 10.1002/ange.201102756
Popis: [EN] Trapped: Mesoporous silica nanoparticles were loaded with a fluorescent guest and functionalized with octadecyltrimethoxysilane. The alkyl chains interact with paraffins, which build a hydrophobic layer around the particle (see picture). Upon melting of the paraffin, the guest molecule is released, as demonstrated in cells for the guest doxorubicin. The release temperature can be tuned by choosing an appropriate paraffin. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Financial support from the Spanish Government (projects MAT2009-14564-C04-01 and SAF2010-15512) and the Generalitat Valenciana (projects PROMETEO/2009/016 and PROMETEO/2010/005) is gratefully acknowledged. L.M. thanks the Generalitat Valenciana for a VALi+d postdoctoral contract. We thank UPV electron microscopy and CIPF confocal microscopy services for technical support.
Databáze: OpenAIRE
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