Left ventricular anatomical and functional changes with ageing in type 2 diabetic adults
| Autor: | Evaggelos Papasteriadis, Kyriaki Baroutsi, John Kalafatis, Komninos Komninos, Stavros Pappas, Alexander Stefanidis, Panagiotis Margos, Stavros Bousboulas |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Aging medicine.medical_specialty Heart disease Systole Heart Ventricles Diastole Doppler imaging Electrocardiography Ventricular Dysfunction Left Internal medicine Diabetes mellitus Diabetic cardiomyopathy medicine Humans Radiology Nuclear Medicine and imaging Aged Analysis of Variance Chi-Square Distribution business.industry General Medicine Middle Aged medicine.disease Echocardiography Doppler Diabetes Mellitus Type 2 Ageing Case-Control Studies Concomitant Cardiology Female Cardiomyopathies Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Journal of Echocardiography. 10:647-653 |
| ISSN: | 1532-2114 1525-2167 |
| DOI: | 10.1093/ejechocard/jep026 |
| Popis: | Aims Previous studies indicate that diabetic patients show evidence of coexisting systolic and diastolic myocardial dysfunction when examined by new echocardiographic techniques. Yet, there is no systematic investigation of the serial age-related changes of left ventricular anatomy and function in this patient population. Methods and results One hundred and sixty type 2 diabetic patients and 110 non-diabetic controls, all with no evidence of heart disease, were studied. The participants were stratified into four distinct age-groups (A: 75 years) and underwent full echocardiographic examination. Conventional systolic and diastolic parameters were similar between the study groups. However, tissue Doppler imaging examination revealed an impaired systolic and diastolic longitudinal myocardial function in diabetic patients vs. controls, although these differences were not noticed within the youngest age-group. Diastolic dysfunction was established concomitantly in both diabetic and control subjects in age-group B. In contrast, diabetic patients showed an earlier induction of myocardial systolic dysfunction, evidenced by significantly lower average systolic longitudinal myocardial velocity in age-group B. Independent predictors of systolic myocardial dysfunction were age, glycated haemoglobin, and systemic blood pressure. Conclusion Type 2 diabetic patients demonstrate an early and concomitant induction of systolic and diastolic myocardial dysfunction as a preclinical manifestation of diabetic cardiomyopathy. |
| Databáze: | OpenAIRE |
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