The clinical value of prostate-specific antigen and bone scintigraphy in the staging of patients with newly diagnosed, pathologically proven prostate cancer
| Autor: | Alberto Baroli, Marco Rudoni, Laura Ciardi, Giuseppina Antonini, Gian Mauro Sacchetti, Michele Favro, Gianni Cardani, Marco Brambilla, Eugenio Inglese |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Bone disease Biopsy Acid Phosphatase Urology Bone Neoplasms Adenocarcinoma Scintigraphy Bone and Bones Prostate cancer Predictive Value of Tests Prostate medicine Humans Radiology Nuclear Medicine and imaging Sampling (medicine) Radionuclide Imaging Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry Prostatic Neoplasms Bone metastasis General Medicine Middle Aged Prostate-Specific Antigen medicine.disease Surgery Prostate-specific antigen medicine.anatomical_structure ROC Curve Bone scintigraphy business |
| Zdroj: | European Journal of Nuclear Medicine. 22:207-211 |
| ISSN: | 1619-7089 0340-6997 |
| DOI: | 10.1007/bf01081514 |
| Popis: | Recent reports suggest that radionuclide bone scan (BS) may not be necessary in the standard staging evaluation of patients with prostate cancer when serum prostate-specific antigen (PSA) levels are normal. To evaluate the ability of PSA to predict BS findings, we retrospectively reviewed the case records of 118 consecutive patients (median age 73 years, range 50-90 years) with newly diagnosed, untreated, pathologically proven prostate cancer who underwent BS and serum PSA sampling within a period of no more than 3 months. Fifty-four out of 118 BSs demonstrated metastatic bone disease. A PSA value of less than 10 ng/ml excluded bone metastasis; of 35 patients with a serum PSA level of 20 ng/ml or less, seven had a positive BS (negative predictive value of 80%). These findings provide additional confirmation of the value of low serum PSA concentrations in excluding the need for a staging BS, although the threshold for a high value of negative predictive accuracy is lower than previously reported. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink