Pyridostigmine bromide protection against acetylcholinesterase inhibition by pesticides
| Autor: | Barry W. Wilson, Imteaz Siddique, John D. Henderson, Bryan Leong, Helen Lam, Gabriela Glucksman, Anna Ankirskaia, Ed DePeters, Andras Tigyi |
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| Rok vydání: | 2011 |
| Předmět: |
Erythrocytes
Health Toxicology and Mutagenesis Pharmacology Protective Agents Toxicology Biochemistry Paraoxon chemistry.chemical_compound Organophosphorus Compounds Malaoxon Soman medicine Animals Pesticides Molecular Biology Organophosphate General Medicine Pesticide Acetylcholinesterase chemistry Malathion Molecular Medicine Diisopropyl fluorophosphate Cattle Pyridostigmine Bromide Chlorpyrifos Cholinesterase Inhibitors medicine.drug |
| Zdroj: | Journal of Biochemical and Molecular Toxicology. 26:31-34 |
| ISSN: | 1095-6670 |
| DOI: | 10.1002/jbt.20410 |
| Popis: | Pyridostigmine bromide (PB) has been used to protect soldiers from the toxic effects of soman, a chemical warfare agent. Recent research shows that pyridostigmine bromide protects a significant percentage of acetylcholinesterase in isolated human intercostal muscle. Findings presented here indicate that red blood cell acetylcholinesterase is similarly protected by pyridostigmine bromide from the action of diisopropyl fluorophosphate and several organophosphate pesticides including chlorpyrifos-oxon, diazinon-oxon, and paraoxon, but not malaoxon, using the bovine red blood cell as a subject. These findings suggest that pretreatment with PB may protect growers, farmworkers, first responders, and the public, in general, from the effects of selected pesticides. |
| Databáze: | OpenAIRE |
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