Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events
| Autor: | Byung Ok Kim, Sung Woo Cho, Byung Gyu Kim, Young Sup Byun, Kun Joo Rhee, Choong Won Goh, Hyuck Moon Kwon, Byoung Kwon Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male lcsh:Diseases of the circulatory (Cardiovascular) system Aterosclerose Coronary Disease Coronary Artery Disease chemistry.chemical_compound High-density lipoprotein Risk Factors Outpatients Medicine Outpatient clinic education.field_of_study Cardiovascular Diseases / adverse events Doenças Cardiovasculares / eventos adversos Sedimentação Sanguínea Middle Aged Glycemic index Cardiovascular Diseases Fibrinogênio Cardiology lipids (amino acids peptides and proteins) Female Cardiology and Cardiovascular Medicine Doença Arterial Coronariana medicine.medical_specialty Other Diagnostic Tests (not involving imaging) Population Blood Sedimentation Statistics Nonparametric Predictive Value of Tests Internal medicine Humans cardiovascular diseases education Glycemic Aged Glycated Hemoglobin business.industry Cholesterol Cholesterol HDL Fibrinogen Reproducibility of Results Original Articles Atherosclerosis Surgery chemistry lcsh:RC666-701 Glycemic Index Hemorheology Glycated hemoglobin business Mace Biomarkers |
| Zdroj: | Arquivos Brasileiros de Cardiologia Arquivos Brasileiros de Cardiologia, Vol 106, Iss 1, Pp 56-61 (2016) Arquivos Brasileiros de Cardiologia v.106 n.1 2016 Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
| ISSN: | 1678-4170 0066-782X |
| Popis: | Background: Hemorheological and glycemic parameters and high density lipoprotein (HDL) cholesterol are used as biomarkers of atherosclerosis and thrombosis. Objective: To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR), fibrinogen, fasting glucose, glycated hemoglobin (HbA1c), and HDL cholesterol in the prediction of major adverse cardiovascular events (MACE) and coronary heart disease (CHD) in an outpatient population. Methods: 708 stable patients who visited the outpatient department were enrolled and followed for a mean period of 28.5 months. Patients were divided into two groups, patients without MACE and patients with MACE, which included cardiac death, acute myocardial infarction, newly diagnosed CHD, and cerebral vascular accident. We compared hemorheological and glycemic parameters and lipid profiles between the groups. Results: Patients with MACE had significantly higher ESR, fibrinogen, fasting glucose, and HbA1c, while lower HDL cholesterol compared with patients without MACE. High ESR and fibrinogen and low HDL cholesterol significantly increased the risk of MACE in multivariate regression analysis. In patients with MACE, high fibrinogen and HbA1c levels increased the risk of multivessel CHD. Furthermore, ESR and fibrinogen were significantly positively correlated with HbA1c and negatively correlated with HDL cholesterol, however not correlated with fasting glucose. Conclusion: Hemorheological abnormalities, poor glycemic control, and low HDL cholesterol are correlated with each other and could serve as simple and useful surrogate markers and predictors for MACE and CHD in outpatients. |
| Databáze: | OpenAIRE |
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