| Autor: |
Pérez-Díez, Irene, Hidalgo, Marta R, Barquín, Miguel, Atocha Romero, Farràs, Rosa, García-García, Francisco |
| Rok vydání: |
2018 |
| DOI: |
10.6084/m9.figshare.7321049.v2 |
| Popis: |
Lung cancer is the most common cause of cancer death worldwide, and 85% of patients belongs to a subtype known as non small cell lung cancer. Although it is greatly associated with smoking, lung cancer in never smokers is more common in women than men. Understanding its biology and molecular mechanisms is crucial for the development of effective therapies and the improvement of its diagnosis.Our approach starts with a systematic review and selection of omics studies available in public repositories such as Gene Expression Omnibus (GEO) and The Cancer GenomeAtlas (TCGA), focusing on microarray and RNA-seq datasets. Then, each study is analyzed in a signaling pathways and molecular functions context to highlight their alterations. Finally, the application of a functional meta-analysis to all results provides a better interpretation in aSystems Biology approach, making it possible to combine the expression meta-analysis with epigenomics data.The results obtained will allow us to know the altered functions in non small cell lung cancer and its gender differences, providing us with the opportunity to determine new and more effective therapeutic targets within the framework of Precision Medicine. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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