The association between ischaemia-modified albumin levels in umbilical vein and intrauterine growth restriction
| Autor: | Cem Yasar Sanhal, Mehmet Simsek, Mehmet Sakinci, Murat Ozekinci, Gulbahar Uzun, Inanc Mendilcioglu, Sebahat Ozdem, O. Karadeniz |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Umbilical Veins medicine.medical_specialty Serum albumin Intrauterine growth restriction Serum Albumin Human Umbilical cord Umbilical vein Young Adult Pregnancy Internal medicine medicine Humans Serum Albumin reproductive and urinary physiology Asphyxia Fetus Fetal Growth Retardation biology Obstetrics business.industry Albumin Obstetrics and Gynecology Hypoxia (medical) medicine.disease female genital diseases and pregnancy complications medicine.anatomical_structure Case-Control Studies biology.protein Cardiology Feasibility Studies Female medicine.symptom business Biomarkers |
| Zdroj: | Journal of Obstetrics and Gynaecology. 35:9-12 |
| ISSN: | 1364-6893 0144-3615 |
| DOI: | 10.3109/01443615.2014.930101 |
| Popis: | Intrauterine growth restriction (IUGR) is one of the most common problems in obstetrics. Ischaemia-modified albumin (IMA), a product deriving from albumin as a result of the modification by oxidative free radicals in response to hypoxia, was previously used as a marker of ischaemia in acute coronary syndrome. We performed this study to determine whether umbilical venous IMA levels are associated with IUGR. A total of 40 pregnancies with IUGR were compared with 40 of normal fetal development. Blood samples were obtained from the umbilical vein after delivery. IMA levels in the IUGR group were higher than in the control group (78.74 ± 6.87 vs 74.43 ± 7.84 U/ml, respectively, p = 0.011). An elevated IMA level was associated with IUGR (OR: 1.079, 95% CI: 1.000-1.163, p = 0.049). We suggest that IMA, which was formerly proved to arise in ischaemic conditions, may also be a valuable marker in perinatal hypoxia and IUGR detection. |
| Databáze: | OpenAIRE |
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