Analysis of Cannabinoid-Containing Fluids in Illicit Vaping Cartridges Recovered from Pulmonary Injury Patients: Identification of Vitamin E Acetate as a Major Diluent
| Autor: | Lingyun Li, David C. Spink, Shijun Lu, Deepika Panawennage, Lorie A. Durocher, Kristen Navarette, David M. LeMaster, Emily Delaney-Baldwin, Bryan C. Duffy, Mark A Dittmar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
vaping cartridges
Health Toxicology and Mutagenesis medicine.medical_treatment Poison control vitamin E acetate Lung injury Toxicology lcsh:Chemical technology Diluent Article 03 medical and health sciences Cartridge cannabinoids 0302 clinical medicine medicine lcsh:TP1-1185 030212 general & internal medicine Vitamin E Acetate Adulterant Chemical Health and Safety Chromatography Chemistry electronic cigarettes 030220 oncology & carcinogenesis Pulmonary Injury Cannabinoid |
| Zdroj: | Toxics Toxics, Vol 8, Iss 1, p 8 (2020) Volume 8 Issue 1 |
| ISSN: | 2305-6304 |
| Popis: | Beginning in June of 2019, there was a marked increase in reported cases of serious pulmonary injury associated with vaping. The condition, referred to as e-cigarette or vaping product use-associated lung injury (EVALI), does not appear to involve an infectious agent rather, a chemical adulterant or contaminant in vaping fluids is suspected. In August of 2019, the Wadsworth Center began receiving vaporizer cartridges recovered from patients with EVALI for analysis. Having no a priori information of what might be in the cartridges, we employed untargeted analyses using gas chromatography-mass spectrometry and high-resolution mass spectrometry to identify components of concern. Additionally, we employed targeted analyses used for New York medical marijuana products. Here, we report on the analyses of 38 samples from the first 10 New York cases of EVALI for which we obtained cartridges. The illicit fluids had relatively low cannabinoid content, sometimes with unusual &Delta 9-/&Delta 8-tetrahydrocannabinol ratios, sometimes containing pesticides and many containing diluents. A notable diluent was &alpha tocopheryl acetate (vitamin E acetate VEA), which was found in 64% of the cannabinoid-containing fluids. To investigate potential sources of the VEA, we analyzed six commercial cannabis-oil diluents/thickeners. Three were found to be > 95% VEA, two were found to be primarily squalane, and one was primarily &alpha bisabolol. The cause(s) of EVALI is unknown. VEA and squalane are components of some personal care products however, there is growing concern that vaping large amounts of these compounds is not safe. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|