Effect of tablets containing probiotic candidate strains on gingival inflammation and composition of the salivary microbiome: a randomised controlled trial
| Autor: | M K Keller, Svante Twetman, E Brandsborg, K Holmstrøm |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine Microbiology (medical) medicine.medical_specialty Saliva Bleeding on probing Hemorrhage Dental plaque Placebo Microbiology Gastroenterology law.invention Placebos Young Adult 03 medical and health sciences Gingivitis 0302 clinical medicine Double-Blind Method Randomized controlled trial Lactobacillus rhamnosus law Internal medicine medicine Humans biology Lacticaseibacillus rhamnosus business.industry Microbiota Probiotics Moderate gingivitis Dental Plaque Index High-Throughput Nucleotide Sequencing Exudates and Transudates 030206 dentistry medicine.disease biology.organism_classification Treatment Outcome 030104 developmental biology Cytokines medicine.symptom business Tablets |
| Zdroj: | Beneficial Microbes. 9:487-494 |
| ISSN: | 1876-2891 1876-2883 |
| DOI: | 10.3920/bm2017.0104 |
| Popis: | The aim of the study was to investigate clinical and microbial effects of probiotic candidate strains in patients with moderate gingivitis. The null hypothesis was that the clinical measurements with treatment would not differ from placebo. 47 adult patients were enrolled in a randomised placebo-controlled trial with a 4-week intervention of tablets containing a mix of Lactobacillus rhamnosus PB01, DSM 14869 and Lactobacillus curvatus EB10, DSM 32307 or placebo. Clinical examinations and samplings were done at baseline and after 2, 4 and 6 weeks. The clinical endpoints were general bleeding on probing (BOP), general plaque index (PI) and flow of gingival crevicular fluid (GCF). In addition, the concentration of selected cytokines (interleukin (IL)-1β, IL-6, IL-8, IL-10, tumour necrosis factor alpha (TNF-α)) in GCF was determined with multiplex immunoassays. The profiles of the salivary microbiome were analysed with Next Generation Sequencing (NGS) and qPCR. In contrast to the placebo group, there was a significant reduction in BOP and amount of GCF (P |
| Databáze: | OpenAIRE |
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