Hemoglobin point-of-care testing in rural Gambia: Comparing accuracy of HemoCue and Aptus with an automated hematology analyzer
| Autor: | Ilias Hossain, Bakary Baldeh, Stefan Akio Nass, Dora I. A. Pereira, Chilel Sanyang |
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| Přispěvatelé: | Nass, Stefan A [0000-0003-3708-7667], Apollo - University of Cambridge Repository |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Rural Population Adolescent Anemia Point-of-care testing Science 030204 cardiovascular system & hematology Hematocrit Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Hematology analyzer Medicine Humans Automation Laboratory Multidisciplinary Receiver operating characteristic medicine.diagnostic_test business.industry Venous blood medicine.disease Iron-deficiency anemia Point-of-Care Testing 030220 oncology & carcinogenesis Hemoglobinometry Female Gambia Hemoglobin business Nuclear medicine |
| Zdroj: | PLoS ONE, Vol 15, Iss 10, p e0239931 (2020) |
| Popis: | BackgroundAnemia is one of the most impactful nutrient deficiencies in the world and disproportionately affects children in low-resource settings. Point-of-care devices (PoCDs) measuring blood hemoglobin (Hb) are widely used in such settings to screen for anemia due to their low cost, speed, and convenience. Here we present the first iteration of Aptus, a new PoCD which measures Hb and hematocrit (HCT).AimTo evaluate the accuracy of Aptus and HemoCue® Hb 301 against an automated hematology analyzer (Medonic®) in Gambian children aged 6-35 months and the Aptus' usage in the field.MethodsAptus, HemoCue® and Medonic® were compared using venous blood (n = 180), and Aptus and HemoCue® additionally using capillary blood (n = 506). Agreement was estimated using Bland-Altman analysis and Lin's concordance. Usage was assessed by error occurrence and user experience.ResultsMean Hb values in venous blood did not significantly differ between Aptus and HemoCue® (10.44±1.05 vs 10.56±0.93g/dl, p>0.05), but both measured higher Hb concentrations than Medonic® (9.75±0.99g/dl, pConclusionBoth PoCDs showed a relatively limited bias but large LoA. Aptus and HemoCue® showed similar accuracy, while both overestimated Hb levels. Aptus showed promise, with its operation unimpaired by field conditions as well as being able to show HCT values. |
| Databáze: | OpenAIRE |
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