Prescription Profile and Clinical Outcomes in Patients with Allergic Rhinitis Treated with Oral Antihistamines or Nasal Corticosteroids
| Autor: | Carlos Castro, Guillermo Sánchez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Estudios de cohortes Mometasone furoate lcsh:Medicine Ciclesonide Levocetirizine perennial allergic rhinitis histamine antagonists 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine cohort studies Prescripciones de medicamentos medicine Medical prescription 030223 otorhinolaryngology Original Research business.industry lcsh:R lcsh:Otorhinolaryngology Dermatology lcsh:RF1-547 Rinitis alérgica perenne Cetirizine drug prescriptions Antagonistas de los receptores histamínicos mometasone furoate Otorhinolaryngology chemistry 030220 oncology & carcinogenesis Cohort Corticosteroid Nasal administration ciclesonide business Furoato de mometasona medicine.drug |
| Zdroj: | International Archives of Otorhinolaryngology International Archives of Otorhinolaryngology, Vol 23, Iss 03, Pp e325-e330 (2019) International Archives of Otorhinolaryngology v.23 n.3 2019 Fundação Otorrinolaringologia (FORL) instacron:FORL Repositorio Digital Institucional ReDi Fundación Universitaria de Ciencias de la Salud-FUCS instacron:Fundación Universitaria de Ciencias de la Salud-FUCS International Archives of Otorhinolaryngology, Volume: 23, Issue: 3, Pages: 325-330, Published: 07 OCT 2019 |
| ISSN: | 1809-4864 1809-9777 |
| DOI: | 10.1055/s-0039-1688968.pdf |
| Popis: | Introduction Oral antihistamines and intranasal corticosteroids have been shown to be effective and safe for the treatment of allergic rhinitis; however, the evidence suggests a level of superiority of corticosteroids, so they should be preferred over the former. Objective To know the prescription profile of two second generation antihistamines (cetirizine and levocetirizine) and two nasal corticosteroids (mometasone and furoate-ciclesonide) in a cohort of patients with allergic rhinitis, and to compare the clinical outcomes obtained. Methods A cohort study was carried including patients with allergic rhinitis treated with cetirizine, levocetirizine, mometasone furoate or ciclesonide. The improvement was evaluated with the total nasal symptoms score (TNSS). This scale yields results between 0 and 12. Zero indicates absence of symptoms. Results A total of 314 patients completed 12 weeks of follow-up. Seventy-five percent were treated with antihistamines, 20% with corticosteroids, and 5% with a combination of the above. The TNSS median for corticosteroid was 2.5 points; for antihistamines, its was 5 points, and for combination, it was 4 points. We found differences between corticosteroids and antihistamines. Conclusion The prescription percentage of second generation oral antihistamines is higher than that of intranasal corticosteroids. However, patients with allergic rhinitis treated with the second option obtained better control of symptoms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|