Behavioral and neuromorphological effects of triethyl tin bromide in adult rats
| Autor: | Hugh A. Tilson, R. E. Squibb, N.G. Carmichael |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Central Nervous System
Male medicine.medical_specialty Hindlimb Toxicology Asymptomatic Water consumption White matter Grip strength chemistry.chemical_compound Bromide Internal medicine medicine Dose group Animals Edema Dosing Pharmacology Behavior Animal Body Weight Rats Endocrinology medicine.anatomical_structure chemistry Tin Anesthesia medicine.symptom |
| Zdroj: | Toxicology and Applied Pharmacology. 55:188-197 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(80)90235-5 |
| Popis: | The repeated administration of triethyl tin bromide (TET) (0, 1.0, 2.0, and 3.0 mg/kg, po) to male rats produced dose- and time-dependent reductions in body weights and food and water consumption. Tests showed decreases in fore- and hindlimb grip strength and startle responsiveness. Histologic examination immediately after the 2-week dosing period showed that in all dose groups there was intramyelinic edema of major CNS white matter tracts, the severity of which varied according to the dose. Four weeks after cessation of TET dosing, body weights of the treatment groups had almost recovered to control group (0 mg/kg) values. These was complete recovery of food and water consumption. Retests for functional performance indicated complete recovery of all measures with the exception of continued reduction of startle responsiveness to an air puff stimulus. Histologic examination after the 4-week recovery period indicated that the 1.0 mg/kg dose group was indistinguishable from controls, while all of the 2.0 mg/kg dose group samples were still moderately edematous. These results demonstrate that specific behavioral tests can show toxic effects of TET in otherwise asymptomatic animals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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