β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in Skeletal Muscle
| Autor: | Chase M. Walton, Jeffery S. Tessem, Eric C.K. Cheung, David M. Thomson, Esther K Wilson, Benjamin T. Bikman, Jacob L Andrus, Michael J. J. Duplisea, Kyle B Kenner, Brian A. Parker, Carrie Draney, Daniel R. Lathen, Sheryl T. Carr |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
ketones Mitochondrion Catalysis Article Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences Mice 0302 clinical medicine β-hydroxybutyrate Oxygen Consumption medicine Myocyte Animals Viability assay Physical and Theoretical Chemistry Muscle Skeletal Molecular Biology lcsh:QH301-705.5 Spectroscopy ceramides 3-Hydroxybutyric Acid Chemistry Myogenesis Organic Chemistry Skeletal muscle General Medicine medicine.disease Computer Science Applications Cell biology Mitochondria Muscle mitochondria 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 Mitochondrial fission Ketosis 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 19, Iss 8, p 2247 (2018) Volume 19 Issue 8 |
| ISSN: | 1422-0067 |
| Popis: | The clinical benefit of ketosis has historically and almost exclusively centered on neurological conditions, lending insight into how ketones alter mitochondrial function in neurons. However, there is a gap in our understanding of how ketones influence mitochondria within skeletal muscle cells. The purpose of this study was to elucidate the specific effects of &beta hydroxybutyrate (&beta HB) on muscle cell mitochondrial physiology. In addition to increased cell viability, murine myotubes displayed beneficial mitochondrial changes evident in reduced H2O2 emission and less mitochondrial fission, which may be a result of a &beta HB-induced reduction in ceramides. Furthermore, muscle from rats in sustained ketosis similarly produced less H2O2 despite an increase in mitochondrial respiration and no apparent change in mitochondrial quantity. In sum, these results indicate a general improvement in muscle cell mitochondrial function when &beta HB is provided as a fuel. |
| Databáze: | OpenAIRE |
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