The G2019S LRRK2 mutation is uncommon amongst Greek patients with sporadic Parkinson's disease
| Autor: | Alexandros Kotsis, Sevasti Bostantjopoulou, Kallirhoe Kalinderi, Liana Fidani, Zoe Katsarou |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Pathology medicine.medical_specialty Pediatrics Parkinson's disease Population Glycine Disease Protein Serine-Threonine Kinases Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Cohort Studies G2019s mutation Serine Humans Medicine education Aged Aged 80 and over education.field_of_study Greece business.industry Parkinson Disease Middle Aged medicine.disease LRRK2 nervous system diseases Amino Acid Substitution Neurology Mutation Mutation (genetic algorithm) Cohort Etiology Female Neurology (clinical) business |
| Zdroj: | European Journal of Neurology. 14:1088-1090 |
| ISSN: | 1468-1331 1351-5101 |
| DOI: | 10.1111/j.1468-1331.2007.01867.x |
| Popis: | Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting approximately 2% of the population > 60 years of age. Although, the etiology of PD is still unknown, the genetic background of the disease has been documented. Recently, a mutation in the LRRK2 gene, G2019S, was associated with 3-41% and 1-2% of familial and sporadic PD, respectively suggesting a pivotal role of LRRK2 in PD. In this report, we examine the association of the G2019S mutation with sporadic late-onset PD, in an independent cohort of Greek patients and controls. |
| Databáze: | OpenAIRE |
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