Striatal dopaminergic system in dopa-responsive dystonia: a multi-tracer PET study shows increased D2 receptors
| Autor: | Kjell Någren, Juha O. Rinne, Hans Helenius, L Vainionpää, L Metsähonkala, Matti Iivanainen, L Pääkkönen |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Dopamine Levodopa 03 medical and health sciences 0302 clinical medicine Dopamine receptor D1 Dopamine receptor D3 Internal medicine Dopamine receptor D2 medicine Humans Child Biological Psychiatry 030304 developmental biology Dopamine transporter Aged Raclopride 0303 health sciences biology Chemistry Receptors Dopamine D2 Dopaminergic Middle Aged Corpus Striatum Psychiatry and Mental health Dystonia Endocrinology Neurology Dopamine receptor biology.protein Female Neurology (clinical) 030217 neurology & neurosurgery medicine.drug Tomography Emission-Computed |
| Zdroj: | Journal of neural transmission (Vienna, Austria : 1996). 111(1) |
| ISSN: | 0300-9564 |
| Popis: | We investigated the integrity of striatal dopaminergic system in seven patients with dopa-responsive dystonia (DRD). Dopamine transporter function ([(11)C]CFT) and D1 ([(11)C]NNC 756) and D2 receptors ([(11)C]raclopride) were studied in same patients using positron emission tomography. Compared to age-adjusted control values the dopamine D2 receptor availability was increased in DRD. The mean age-adjusted [(11)C]raclopride uptake was 116% of the control mean in the putamen (p = 0.004) and 114% in the caudate nucleus (p = 0.007). The mean [(11)C]NNC 756 uptake was not different between DRD patients and controls, the age-adjusted uptake in DRD being 93% of mean control value in the putamen (p = 0.20) and 95% in the caudate nucleus (p = 0.40). The dopamine transporter binding was not altered. The [(11)C]CFT uptake in DRD was 96% of the control value in the putamen (p = 0.64), and 95% in the caudate nucleus (p = 0.44). In conclusion, striatal dopamine D2 receptors availability is increased in DRD whereas dopamine D1 receptors and dopamine transporter ligand binding is unchanged. The pattern of changes in striatal dopaminergic system in DRD is different from that reported in juvenile Parkinson's disease. The increased D2 receptor availability may be due to reduced competition by endogenous dopamine or a compensatory response to dopamine deficiency, or both. |
| Databáze: | OpenAIRE |
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