The correlation of biochemical and morphologic parameters in the assessment of sperm maturity
| Autor: | Bogomir Milojevic, Otas Durutovic, Sava Micic, N. Lalic, Dragica Milenkovic-Petronic, Zoran Dzamic, Nebojsa Ladjevic, Ana Mimic, Lidija Tulić, D. Djordjevic, Nebojsa Bojanic |
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| Rok vydání: | 2013 |
| Předmět: |
Infertility
Male Urology media_common.quotation_subject Fertility Sensitivity and Specificity Correlation Andrology 03 medical and health sciences 0302 clinical medicine medicine Humans Maturation process Creatine Kinase Infertility Male 030304 developmental biology media_common 0303 health sciences 030219 obstetrics & reproductive medicine biology urogenital system business.industry Area under the curve Creatine Kinase MM Form medicine.disease Sperm Spermatozoa Sperm Maturation ROC Curve Sperm Tail biology.protein Sperm morphology Sperm Head Creatine kinase business |
| Zdroj: | Urology. 82(6) |
| ISSN: | 1527-9995 |
| Popis: | To examine the relationship between biochemical markers and morphologic sperm characteristics, including head, neck, and tail changes.The study evaluated 154 patients who went to the Andrology Laboratory of the Clinic of Urology, Clinical Center of Serbia. Patients were divided into 4 groups: normozoospermic, oligozoospermic, severe oligozoospermic, and asthenozoospermic, according to the sperm concentration and motility.The differences in creatine kinase (CK) and CK-M levels between normozoospermic and the 2 groups of oligozoospermic patients were significantly different (P.01). The CK and CK-M levels correlated negatively with sperm concentration and sperm motility, but correlated positively with the pathologic sperm form. Patients with CK values0.093 have a total number of pathologic forms higher than 0.40 (87.5% sensitivity, 77.3% specificity, the area under the curve was 0.832, P.001). Patients with CK values0.09 U/L have normal spermatogenesis and pathologic disorder of the head15%, neck12%, and tail10%.The relation between sperm morphology and biochemical markers included in the maturation process is established during the sperm genesis process. If the results of these markers are used together with the morphology of the spermatozoa in the interpretation of infertility, it would lead us to better insight of the fertility potential of the each patient. |
| Databáze: | OpenAIRE |
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