Focal application of accelerated iTBS results in global changes in graph measures
| Autor: | Deborah C.W. Klooster, Karen Caeyenberghs, René M.H. Besseling, Chris Baeken, Albert P. Aldenkamp, Jaap F.A. Jansen, Suzanne L. Franklin, Paul Boon, Anton J.A. de Louw, Romain Duprat |
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| Přispěvatelé: | Brain, Body and Cognition, Clinical sciences, Neuroprotection & Neuromodulation, Psychiatry, Video Coding & Architectures, Electrical Engineering, Signal Processing Systems, Center for Care & Cure Technology Eindhoven, Beeldvorming, MUMC+: DA BV Klinisch Fysicus (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Klinische Neurowetenschappen |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Power graph analysis
TRANSCRANIAL MAGNETIC STIMULATION medicine.medical_treatment LATE-LIFE DEPRESSION Stimulation Severity of Illness Index Placebos Depressive Disorder Treatment-Resistant 0302 clinical medicine transcranial magnetic stimulation Medicine and Health Sciences THETA-BURST STIMULATION Theta Rhythm Default mode network Research Articles MAJOR DEPRESSIVE DISORDER Cross-Over Studies Radiological and Ultrasound Technology 05 social sciences Late life depression Magnetic Resonance Imaging graph analysis ORBITOFRONTAL CORTEX medicine.anatomical_structure Radiology Nuclear Medicine and imaging STRUCTURAL NETWORKS Graph (abstract data type) DEFAULT MODE Research Article Adult medicine.medical_specialty anatomy DORSOLATERAL PREFRONTAL CORTEX Clinical Neurology 050105 experimental psychology 03 medical and health sciences Physical medicine and rehabilitation Double-Blind Method medicine Connectome Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Neuronavigation Clustering coefficient HF-RTMS TREATMENT business.industry neurology functional connectivity Biology and Life Sciences Evoked Potentials Motor Dorsolateral prefrontal cortex Transcranial magnetic stimulation Neurology (clinical) Nerve Net accelerated intermittent theta burst stimulation business 030217 neurology & neurosurgery |
| Zdroj: | Human Brain Mapping Human Brain Mapping, 40(2), 432-450. Wiley-Liss Inc. Human Brain Mapping, 40(2), 432-450. Wiley HUMAN BRAIN MAPPING |
| ISSN: | 1065-9471 1097-0193 |
| Popis: | Graph analysis was used to study the effects of accelerated intermittent theta burst stimulation (aiTBS) on the brain's network topology in medication‐resistant depressed patients. Anatomical and resting‐state functional MRI (rs‐fMRI) was recorded at baseline and after sham and verum stimulation. Depression severity was assessed using the Hamilton Depression Rating Scale (HDRS). Using various graph measures, the different effects of sham and verum aiTBS were calculated. It was also investigated whether changes in graph measures were correlated to clinical responses. Furthermore, by correlating baseline graph measures with the changes in HDRS in terms of percentage, the potential of graph measures as biomarker was studied. Although no differences were observed between the effects of verum and sham stimulation on whole‐brain graph measures and changes in graph measures did not correlate with clinical response, the baseline values of clustering coefficient and global efficiency showed to be predictive of the clinical response to verum aiTBS. Nodal effects were found throughout the whole brain. The distribution of these effects could not be linked to the strength of the functional connectivity between the stimulation site and the node. This study showed that the effects of aiTBS on graph measures distribute beyond the actual stimulation site. However, additional research into the complex interactions between different areas in the brain is necessary to understand the effects of aiTBS in more detail. |
| Databáze: | OpenAIRE |
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