In vitro pharmacological and toxicological effects of Norterpene Peroxides isolated from the Red Sea sponge Diacarnus erythraeanus on normal and cancer cells
| Autor: | Maria Letizia Ciavatta, Gwendoline Van Goietsenoven, Véronique Mathieu, Guido Villani, Genoveffa Nuzzo, Issa M. I. Fakhr, Robert Kiss, Rob W. M. Van Soest, Florence Lefranc, Nehal A. Hamdy, Laetitia Moreno Y Banuls |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Stereochemistry
Pharmaceutical Science Video microscopy Antineoplastic Agents Apoptosis biological activity Biology Peroxide Diacarnus erythraeanus Analytical Chemistry Flow cytometry sponge chemistry.chemical_compound Inhibitory Concentration 50 Drug Discovery medicine Animals Humans IC50 Indian Ocean Pharmacology medicine.diagnostic_test Molecular Structure Terpenes secondary metabolites Organic Chemistry muqubilin Molecular biology In vitro Peroxides Porifera Complementary and alternative medicine chemistry Cell culture Cancer cell Molecular Medicine Drug Screening Assays Antitumor Reactive Oxygen Species |
| Zdroj: | Journal of natural products 76 (2013): 1541–1547. doi:10.1021/np400107t info:cnr-pdr/source/autori:Florence Lefranc, Genoveffa Nuzzo, Nehal Aly Hamdy, Issa Fakhr, Laetitia Moreno Y Banuls, Gwendoline Van Goietsenoven, Guido Villani, Ve?ronique Mathieu, Rob van Soest, Robert Kiss, and Maria Letizia Ciavatta/titolo:In Vitro Pharmacological and Toxicological Effects of Norterpene Peroxides Isolated from the Red Sea Sponge Diacarnus erythraeanus on Normal and Cancer Cells./doi:10.1021%2Fnp400107t/rivista:Journal of natural products (Print)/anno:2013/pagina_da:1541/pagina_a:1547/intervallo_pagine:1541–1547/volume:76 |
| DOI: | 10.1021/np400107t |
| Popis: | Eight cyclic peroxide norterpenoids, compounds 1-8, have been isolated and characterized from the Red Sea sponge Diacarnus erythraeanus, including two new norsesterterpene derivatives (3, 4). Among these metabolites, (-)-muqubilin A (5) (nine cell lines analyzed) and the new compounds 3 and 4 (seven cell lines analyzed) displayed mean IC50 growth inhibitory concentrations in vitro of in vitro growth inhibition. Quantitative video microscopy analysis carried out on (-)-muqubilin A-treated cells validated the data obtained by means of the MTT colorimetric assay, while flow cytometry analysis revealed ROS production but no induction of apoptosis in cancer cells. |
| Databáze: | OpenAIRE |
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