Rapid Whole-Genome Sequencing for Investigation of a Suspected Tuberculosis Outbreak

Autor:	M. Estée Török, Bernadette Nazareth, Julian Parkhill, Geoffrey Paul Smith, Josephine M. Bryant, Sian V. Stinchcombe, Sharon J. Peacock, Sandra Reuter, Claudio U. Köser, Stephen D. Bentley, Matthew J. Ellington
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	Microbiology (medical) Adult Male medicine.medical_specialty Tuberculosis education Drug resistance Biology Southeast asian Disease Outbreaks Mycobacterium tuberculosis Young Adult Epidemiology medicine Humans Phylogeny Whole genome sequencing Transmission (medicine) Outbreak Mycobacteriology and Aerobic Actinomycetes Sequence Analysis DNA medicine.disease biology.organism_classification Virology United Kingdom Genome Bacterial
Popis:	Two Southeast Asian students attending the same school in the United Kingdom presented with pulmonary tuberculosis. An epidemiological investigation failed to link the two cases, and drug resistance profiles of the Mycobacterium tuberculosis isolates were discrepant. Whole-genome sequencing of the isolates found them to be genetically identical, suggesting a missed transmission event.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27adfbd838e7c747fc6be60d0de7e383 https://europepmc.org/articles/PMC3553910/ Zobrazit plný text záznamu