NO-Independent stimulators of soluble guanylate cyclase

Autor:	Cristina Alonso-Alija, Johannes-Peter Stasch, Bernhard Ducke, Achim Feurer, Jordi Benet-Buchholz, Alexander Straub, Chantal Fürstner
Rok vydání:	2001
Předmět:	GUCY1B3 Indazoles Pyridines Clinical Biochemistry Enzyme Activators Pharmaceutical Science Pharmacology Biochemistry Structure-Activity Relationship In vivo medicine.artery Drug Discovery medicine Animals Molecular Biology Aorta Lagomorpha biology Chemistry Organic Chemistry GUCY1A3 Guanylate cyclase 2C biology.organism_classification Vasodilation medicine.anatomical_structure Guanylate Cyclase Pyrazoles Molecular Medicine GUCY2D Rabbits Blood vessel
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 11:781-784
ISSN:	0960-894X
Popis:	SARs around a novel type of guanylate cyclase stimulator which act by a mechanism different from classical NO-donors are described. Several pyrazolopyridinylpyrimidines are shown to relax aortic rings and revealed a long-lasting blood pressure lowering effect in rats after oral application.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27abfc37593d8c8dde71eddba619f746 https://doi.org/10.1016/s0960-894x(01)00073-7 Zobrazit plný text záznamu Full Text from ScienceDirect