Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis

Autor: Amandine Gautier-Stein, F. Plessier, Gilles Mithieux, F. De Vadder
Přispěvatelé: Di Carlo, Marie-Ange, Université de Lyon, Nutrition et cerveau (U1213, U855), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), The authors thank the CNRS (G.M.), the INRA (A.G.-S.), the Ministère de l’Enseignement Supérieur et de la Recherche (F.D.V.), and the Ecole Normale Supérieure de Lyon (F.P.) for funding their positions. This work was funded by the INSERM.
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Neurogastroenterology & Motility
Neurogastroenterology & Motility, Wiley, 2015, 27 (3), pp.443-448. ⟨10.1016/j.molmet.2014.12.009⟩
ISSN: 1350-1925
1365-2982
Popis: Intestinal gluconeogenesis (IGN) promotes metabolic benefits through activation of a gut-brain neural axis. However, the local mediator activating gluconeogenic genes in the enterocytes remains unknown. We show that (i) vasoactive intestinal peptide (VIP) signaling through VPAC1 receptor activates the intestinal glucose-6-phosphatase gene in vivo, (ii) the activation of IGN by propionate is counteracted by VPAC1 antagonism, and (iii) VIP-positive intrinsic neurons in the submucosal plexus are increased under the action of propionate. These data support the role of VIP as a local neuromodulator released by intrinsic enteric neurons and responsible for the induction of IGN through a VPAC1 receptor-dependent mechanism in enterocytes.
Databáze: OpenAIRE