Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis
Autor: | Amandine Gautier-Stein, F. Plessier, Gilles Mithieux, F. De Vadder |
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Přispěvatelé: | Di Carlo, Marie-Ange, Université de Lyon, Nutrition et cerveau (U1213, U855), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), The authors thank the CNRS (G.M.), the INRA (A.G.-S.), the Ministère de l’Enseignement Supérieur et de la Recherche (F.D.V.), and the Ecole Normale Supérieure de Lyon (F.P.) for funding their positions. This work was funded by the INSERM. |
Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Male
medicine.medical_specialty Receptors Vasoactive Intestinal Polypeptide Type I Physiology Vasoactive intestinal peptide Gut–brain axis Enteric Nervous System Rats Sprague-Dawley Mediator In vivo Internal medicine Intestinal gluconeogenesis medicine Animals [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Gene vasoactive intestinal peptide Neurons chemistry.chemical_classification biology Endocrine and Autonomic Systems gut-brain axis Gluconeogenesis Gastroenterology glucose-6- phosphatase KEY MESSAGES Jejunum Endocrinology chemistry Glucose-6-Phosphatase biology.protein Propionate [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Antagonism Glucose 6-phosphatase |
Zdroj: | Neurogastroenterology & Motility Neurogastroenterology & Motility, Wiley, 2015, 27 (3), pp.443-448. ⟨10.1016/j.molmet.2014.12.009⟩ |
ISSN: | 1350-1925 1365-2982 |
Popis: | Intestinal gluconeogenesis (IGN) promotes metabolic benefits through activation of a gut-brain neural axis. However, the local mediator activating gluconeogenic genes in the enterocytes remains unknown. We show that (i) vasoactive intestinal peptide (VIP) signaling through VPAC1 receptor activates the intestinal glucose-6-phosphatase gene in vivo, (ii) the activation of IGN by propionate is counteracted by VPAC1 antagonism, and (iii) VIP-positive intrinsic neurons in the submucosal plexus are increased under the action of propionate. These data support the role of VIP as a local neuromodulator released by intrinsic enteric neurons and responsible for the induction of IGN through a VPAC1 receptor-dependent mechanism in enterocytes. |
Databáze: | OpenAIRE |
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