Carotenoid Intake and Esophageal Cancer Risk: a Meta-analysis
| Autor: | Xiao-Xiao Ge, Lan-Fang Yu, Mei-Yuan Xing, Peng Shen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
medicine.medical_specialty Lutein Esophageal Neoplasms Epidemiology Cochrane Library Lower risk Gastroenterology Antioxidants chemistry.chemical_compound Risk Factors Internal medicine Humans Medicine Carotenoid chemistry.chemical_classification business.industry Public Health Environmental and Occupational Health Esophageal cancer Prognosis medicine.disease Carotenoids Lycopene Zeaxanthin Oncology chemistry Biochemistry Meta-analysis business |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 14:1911-1918 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2013.14.3.1911 |
| Popis: | This meta-analysis was conducted to evaluate the association between intake of carotenoids and risk of esophageal cancer. A systematic search using PubMed, Cochrane Library, Web of Science, Scopus, CNKI, and CBM (updated to 6 May 2012) identified ten articles meeting the inclusion criteria with 1,958 cases of esophageal cancer and 4,529 controls. Higher intake of beta-carotene, alpha-carotene, lycopene, beta-cryptoxanthin, lutein, and zeaxanthin reduced esophageal cancer risk with pooled ORs of 0.58 (95% CI 0.44, 0.77), 0.81 (95% CI 0.70, 0.94), 0.75 (95% CI 0.64, 0.86), 0.80 (95% CI 0.66, 0.97), and 0.71 (95% CI 0.59, 0.87), respectively. In subgroup analyses, beta-carotene showed protective effects against esophageal adenocarcinoma in studies located in Europe and North America. Alpha-carotene, lycopene, and beta-cryptoxanthin showed protection against esophageal squamous cell cancer. This meta-analysis suggested that higher intake of carotenoids (beta-carotene, alpha- carotene, lycopene, beta-cryptoxanthin, lutein, and zeaxanthin) is associated with lower risk of esophageal cancer. Further research with large-sample studies need to be conducted to better clarify the potentially protective mechanisms of carotenoid associations risk of different types of esophageal cancer. |
| Databáze: | OpenAIRE |
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